The NGS Data Consortium is composed of stakeholders in the application of Next Generation Sequencing (NGS) technology for genotyping the HLA and KIR loci as well as other immune-related loci (these are referred to collectively as immunogenomic loci).

The goal in assembling this consortium has been to initiate strategic discussions regarding the changes that NGS-based immunogenomic genotyping will bring to the fields of Histocompatibility and Immunogenetics. Data standards must be established in order to ensure that NGS data can be used most effectively, and these meetings are meant to begin the process of drafting them. It is important to note that this consortium and any standards it produces are germane to the data generated by NGS platforms, and not the technology and methodology specific to individual NGS platforms.

The consortium achieved the following objectives in 2012 and 2013:

On September 26th and 27th of 2014, the draft Minimum Information for Reporting Immunogenomic NGS Genotyping (MIRING) guidelines were vetted and updated as part of the first Data Standards Hackathon for NGS based typing of HLA & KIR (DaSH for NGS) held in conjunction with the FDA Workshop on NGS Standards.

The goal of the hackathon was to develop a toolset that was integrated with the various NGS systems and analysis software packages currently in use, the specific aims of achieving interoperability for the histocompatibility and immunogenetics community, vetting HML 1.0 and vetting MIRING.

Hackathon attendees provided feedback on:

MIRING version 2 was developed as part of these DaSH for NGS efforts.

This new version of MIRING defines 8 elements of a message that capture the minimum information necessary to report a NGS HLA or KIR genotype.

On September 24, 2014, the draft MIRING reporting guidelines were presented at the Food and Drug Administration's Public Workshop on Next Generation Sequencing Data Standards in Bethesda, MD by Dr. Steven J. Mack.
On June 26, 2014, the draft MIRING data reporting guidelines were presented at the European Federation for Immunogenetics meetin in Stockholm, Sweden by Benjamin D. Gifford in Abstract session 2: Bioinformatics.

Read the Minimum Information for Reporting Immunogenomic NGS Genotyping (MIRING) minimum information reporting guidelines, and appendices. In November of 2013, this draft of an information standard (and related appendices), as well as a letter of comment on the Draft NIH Genomic Data Sharing (GDS) Policy that had been drafted by the IDAWG and the ASHI Scientific Affairs Committee, was circulated to the consortium participants for review and comment in advance of the November 17th meeting.


Sunday, November 17, 2013.
Chicago, Illinois, USA

Presentation/Discussion of the Data Standard Implementation Validation and Testing of the Standard

The participants of the consortium agreed to submit the final version of the letter of comment on the Draft NIH GDS Policy on behalf of the Immunogenomic NGS Data Consortium.

Tuesday, May 14, 2013.
Maastricht, The Netherlands

Introduction Data standards for the field as a whole

Monday October 8, 2012.
San Juan, Puerto Rico, USA

How and what kind of data we generate How do we analyze data? What data should we collect, and how?