MIRING is a set of MIBBI
reporting guidelines developed by the Immunogenomic NGS Data Consortium
, a collaboration of immunogenomic researchers and clinicians, NGS instrument manufacturers and software developers, HLA and KIR sequence database developers and administrators, bone marrow donor registries and donor centers.
The paper describing MIRING, Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping
via next generation sequencing,
published by Mack et al. (2015), is available under a
CC BY 4.0 License, thanks to the generous support of GenDX,
the National Marrow Donor Program,
Omixon, and Roche Sequencing.
This paper defines eight categories of information needed to describe an NGS HLA and KIR genotyping result, ensuring the long-term portability and broad application of NGS genotyping data for histocompatibility, immunogenetic and immunogenomic applications.
|Method Independent||Method Independent||NGS Specific|
|1. MIRING Annotation||3. Full Genotype||6. Platform Documentation|
|2. Reference Context||4. Consensus Sequence||7. Read Processing Documentation|
|5. Novel Polymorphism||8. Primary Data|
The data defined in MIRING categories 1-5 should be included in any message used to exchange NGS genotyping results or generate an NGS genotyping report for HLA and KIR data, along with instructions for obtaining the data in MIRING categories 6-8.
Although data categories 6-8 are specific to NGS technologies, MIRING can be extended to incorporate genotyping data generated via older HLA and KIR genotyping technologies.
MIRING development was supported by National Institutes of Health grants U01AI067068, U01AI090905 and R01GM109030, and Office of Naval Research grant N00014-08-1-1207.
Please email questions or comments regarding MIRING to SJ Mack.
Support for the OnlineOpen status of Mack et. al. (2015) has been generously provided by